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Subacute toxicity research in canine for 4 weeks at 480 mg/kg day-to-day confirmed no specific changes; at 960 mg/kg, two away from eight died with proof of circulatory collapse. This broad margin of safety is important in comparison to chlordiazepoxide HCl, which confirmed nonspecific alterations in 6 puppies at eighty mg/kg.Healthful Minds System